Originally published on 10/7/25

Silencing food noise can be hard, especially when there are so many delicious temptations both at home and at restaurants. But new research published last month suggests that there might finally be a way to quiet that urge to overeat for good. In a German study published in the journal Nature Communications, scientists revealed how a protein called melanocortin 2 receptor accessory protein (MRAP2) helps “regulate feelings of hunger” in the brain. We asked doctors what the discovery means for the future of weight loss meds and how you can curb cravings naturally.  

What the research shows about quieting hunger signals 

Scientists recently discovered that the MRAP2 protein affects a brain receptor known as the melanocortin-4 receptor (MC4R), which helps eliminate feelings of hunger.

So what exactly does the research mean for us? 

“This exciting study identifies another pathway in the brain that helps regulate appetite and body weight. MRAP2 is a protein that helps MC4R move to the cell surface so it can send stronger ‘stop-eating’ signals,” says Holly Wyatt, MD, physician, endocrinologist and co-author of Losing The Weight Loss Meds. “That means MRAP2 amplifies one of the body’s natural ‘hunger-off’ switches. Discoveries like this open the door to potential new medications that target MRAP2 and offer a completely different tool than GLP-1 medications for appetite and weight management.” 

Why that’s so important: “When MRAP2 isn’t functioning properly, animal and human studies have shown that individuals may experience increased appetite and weight gain despite normal food intake,” explains Mark Kovacs, MD. “Essentially, MRAP2 acts as a ‘brake’ in the hunger system. This brake helps the brain properly interpret energy needs and satiety cues. This doesn’t mean that MRAP2 itself is something you can supplement or ‘consume,’ but rather that it’s a key signaling molecule inside the body.” 

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Natural ways to curb hunger and avoid overeating

Since MRAP2 is found in the brain, Dr. Wyatt says it’s “not something you get from food. It is a protein your body makes.” 

And while researchers haven’t yet developed a medication that targets MRAP2 to shut off hunger signals, there are other ways to reduce your appetite and avoid overeating naturally. “Dietary protein still matters for appetite control because it stimulates satiety hormones and helps people feel full longer,” Dr. Wyatt says. “High-quality sources like lean meats, fish, eggs, beans and dairy are excellent ways to boost satiety naturally. This study reminds us that appetite is regulated by many overlapping systems, which is why different approaches, including food, activity and emerging therapies, can all play a role in weight management.” 

Aside from increasing your fiber and protein intake, Dr. Kovacs recommends getting “adequate sleep, since sleep deprivation elevates ghrelin (the hunger hormone) and suppresses leptin (the fullness hormone). Hydration and balanced blood sugar [are also important], since both dehydration and blood sugar fluctuations can mimic hunger signals.” 

The bottom line: “The future of appetite and weight regulation will likely focus on these neural and hormonal networks, including MRAP2,” says Dr. Kovacs. “For now, lifestyle strategies that balance nutrition, sleep and stress remain the most effective ways to keep hunger in check and energy stable.” 

Link to original: https://www.womansworld.com/wellness/new-study-finds-protein-that-could-quiet-food-noise-for-good